4ZTE

Crystal structure of human E-Cadherin (residues 3-213) in complex with a peptidomimetic inhibitor

Summary for 4ZTE

Entry DOI	10.2210/pdb4zte/pdb
Related	4ZT1
Descriptor	Cadherin-1, CALCIUM ION, N-{[(2S,5S)-1-benzyl-5-(2-{[(2S,3S)-1-(tert-butylamino)-3-methyl-1-oxopentan-2-yl]amino}-2-oxoethyl)-3,6-dioxopiperazin-2-yl]methyl}-L-alpha-asparagine, ... (4 entities in total)
Functional Keywords	adhesion, cadherin, calcium-binding protein, x-dimer, inhibitor, peptidomimetic, cell adhesion
Biological source	Homo sapiens (Human)
Cellular location	Cell junction: P12830
Total number of polymer chains	2
Total formula weight	47088.66
Authors	Nardone, V.,Lucarelli, A.P.,Dalle Vedove, A.,Parisini, E. (deposition date: 2015-05-14, release date: 2016-06-01, Last modification date: 2024-01-10)
Primary citation	Nardone, V.,Lucarelli, A.P.,Dalle Vedove, A.,Fanelli, R.,Tomassetti, A.,Belvisi, L.,Civera, M.,Parisini, E. Crystal Structure of Human E-Cadherin-EC1EC2 in Complex with a Peptidomimetic Competitive Inhibitor of Cadherin Homophilic Interaction. J.Med.Chem., 59:5089-5094, 2016 Cited by PubMed: 27120112 DOI: 10.1021/acs.jmedchem.5b01487 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.13 Å)

Structure validation