4ZOL

Crystal Structure of Tubulin-Stathmin-TTL-Tubulysin M Complex

Summary for 4ZOL

• Entry DOI: 10.2210/pdb4zol/pdb
• Related: 4ZHQ 4ZI7 5BMV
• Related PRD ID: PRD_002237
• Descriptor: Tubulin alpha-1B chain, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, (2R,4R)-4-{[(2-{(1R,3R)-1-(acetyloxy)-4-methyl-3-[methyl(N-{[(2S)-1-methylpiperidin-2-yl]carbonyl}-D-isoleucyl)amino]pentyl}-1,3-thiazol-4-yl)carbonyl]amino}-2-methyl-5-phenylpentanoic acid, ... (13 entities in total)
• Functional Keywords: structural protein-inhibitor complex, structural protein/inhibitor
• Biological source: Rattus norvegicus (Rat); More
• Cellular location: Cytoplasm, cytoskeleton: Q2XVP4 P02554; Golgi apparatus : P63043
• Total number of polymer chains: 6
• Total formula weight: 266553.47

Authors

Wang, Y.,Zhang, R. (deposition date: 2015-05-06, release date: 2016-07-27, Last modification date: 2024-03-20)

• Primary citation: Wang, Y.,Benz, F.W.,Wu, Y.,Wang, Q.,Chen, Y.,Chen, X.,Li, H.,Zhang, Y.,Zhang, R.,Yang, J.; Structural Insights into the Pharmacophore of Vinca Domain Inhibitors of Microtubules; Mol.Pharmacol., 89:233-242, 2016; PubMed: 26660762; DOI: 10.1124/mol.115.100149

Experimental method

X-RAY DIFFRACTION (2.5 Å)