4ZOG

VX-680/MK-0457 binds to human ABL1 also in inactive DFG conformations.

Summary for 4ZOG

• Entry DOI: 10.2210/pdb4zog/pdb
• Descriptor: Tyrosine-protein kinase ABL1, CYCLOPROPANECARBOXYLIC ACID {4-[4-(4-METHYL-PIPERAZIN-1-YL)-6-(5-METHYL-2H-PYRAZOL-3-YLAMINO)-PYRIMIDIN-2-YLSULFANYL]-PHENYL}-AMIDE, 2-METHOXYETHANOL, ... (5 entities in total)
• Functional Keywords: kinase, transferase, abl1, dfg conformations
• Biological source: Homo sapiens (Human)
• Cellular location: Cytoplasm, cytoskeleton. Isoform IB: Nucleus membrane; Lipid-anchor: P00519
• Total number of polymer chains: 2
• Total formula weight: 66887.51

Authors

Kyomuhendo, P.,Narayanan, D.,Engh, R.A. (deposition date: 2015-05-06, release date: 2016-09-14, Last modification date: 2024-01-10)

• Primary citation: Kyomuhendo, P.,Narayanan, D.,Engh, R.A.; VX-680/MK-0457 binds also to human ABL1 with inactive DFG conformations.; To Be Published,

Experimental method

X-RAY DIFFRACTION (2.3 Å)