4ZKL

Crystal structure of human histidine triad nucleotide-binding protein 1 (hHINT1) complexed with JB419 (AP4A analog)

Summary for 4ZKL

Entry DOI	10.2210/pdb4zkl/pdb
Related	1KPC 3TW2
Descriptor	Histidine triad nucleotide-binding protein 1, ADENOSINE MONOPHOSPHATE, (2R,3R,4S,5R)-2-(6-aminopurin-9-yl)-5-[2-[[(2S)-3-[[(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methoxy-sulfanyl-phosphoryl]oxy-2-oxidanyl-propoxy]-sulfanyl-phosphoryl]oxyethyl]oxolane-3,4-diol, ... (4 entities in total)
Functional Keywords	hint, hit, hydrolase, phosphoramidase, complex, ap4a analog
Biological source	Homo sapiens (Human)
Cellular location	Cytoplasm: P49773
Total number of polymer chains	4
Total formula weight	56786.83
Authors	Dolot, R.M.,Kaczmarek, R.,Seda, A.,Krakowiak, A.,Baraniak, J.,Nawrot, B. (deposition date: 2015-04-30, release date: 2016-03-02, Last modification date: 2024-01-10)
Primary citation	Dolot, R.,Kaczmarek, R.,Seda, A.,Krakowiak, A.,Baraniak, J.,Nawrot, B. Crystallographic studies of the complex of human HINT1 protein with a non-hydrolyzable analog of Ap4A. Int.J.Biol.Macromol., 87:62-69, 2016 Cited by PubMed: 26905466 DOI: 10.1016/j.ijbiomac.2016.02.047 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.34 Å)

Structure validation