4ZI7

CRYSTAL STRUCTURE OF TUBULIN-STATHMIN-TTL-HTI286 COMPLEX

Summary for 4ZI7

• Entry DOI: 10.2210/pdb4zi7/pdb
• Related: 4ZHQ 4ZOL 5BMV
• Related PRD ID: PRD_002175
• Descriptor: Tubulin alpha-1B chain, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, N,beta,beta-trimethyl-L-phenylalanyl-N-[(3S,4Z)-5-carboxy-2-methylhex-4-en-3-yl]-N,3-dimethyl-L-valinamide, ... (13 entities in total)
• Functional Keywords: structural protein-inhibitor complex, structural protein/inhibitor
• Biological source: Rattus norvegicus (Rat); More
• Cellular location: Cytoplasm, cytoskeleton: Q2XVP4 P02554; Golgi apparatus : P63043
• Total number of polymer chains: 6
• Total formula weight: 265743.46

Authors

Wang, Y.,Zhang, R. (deposition date: 2015-04-27, release date: 2016-07-27, Last modification date: 2024-03-20)

• Primary citation: Wang, Y.,Benz, F.W.,Wu, Y.,Wang, Q.,Chen, Y.,Chen, X.,Li, H.,Zhang, Y.,Zhang, R.,Yang, J.; Structural Insights into the Pharmacophore of Vinca Domain Inhibitors of Microtubules; Mol.Pharmacol., 89:233-242, 2016; PubMed: 26660762; DOI: 10.1124/mol.115.100149

Experimental method

X-RAY DIFFRACTION (2.51 Å)