4ZGX

Structure of aldosterone synthase (CYP11B2) in complex with (+)-(R)-N-(4-(4-chloro-3-fluorophenyl)-5,6,7,8-tetrahydroisoquinolin-8-yl)propionamide

Summary for 4ZGX

Entry DOI	10.2210/pdb4zgx/pdb
Descriptor	Cytochrome P450 11B2, mitochondrial, PROTOPORPHYRIN IX CONTAINING FE, N-[(8R)-4-(4-chloro-3-fluorophenyl)-5,6,7,8-tetrahydroisoquinolin-8-yl]propanamide, ... (4 entities in total)
Functional Keywords	cytochrome p450, cyp11b2, aldosterone synthase, oxidoreductase
Biological source	Homo sapiens (Human)
Cellular location	Mitochondrion membrane: P19099
Total number of polymer chains	12
Total formula weight	685632.23
Authors	Kuglstatter, A.,Joseph, C. (deposition date: 2015-04-24, release date: 2015-10-07, Last modification date: 2015-11-04)
Primary citation	Martin, R.E.,Aebi, J.D.,Hornsperger, B.,Krebs, H.J.,Kuhn, B.,Kuglstatter, A.,Alker, A.M.,Marki, H.P.,Muller, S.,Burger, D.,Ottaviani, G.,Riboulet, W.,Verry, P.,Tan, X.,Amrein, K.,Mayweg, A.V. Discovery of 4-Aryl-5,6,7,8-tetrahydroisoquinolines as Potent, Selective, and Orally Active Aldosterone Synthase (CYP11B2) Inhibitors: In Vivo Evaluation in Rodents and Cynomolgus Monkeys. J.Med.Chem., 58:8054-8065, 2015 Cited by PubMed: 26403853 DOI: 10.1021/acs.jmedchem.5b00851 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (3.2 Å)

Structure validation