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4ZG6

Structural basis for inhibition of human autotaxin by four novel compounds

Summary for 4ZG6
Entry DOI10.2210/pdb4zg6/pdb
Related4ZG7 4ZG9 4ZGA
DescriptorEctonucleotide pyrophosphatase/phosphodiesterase family member 2, beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ZINC ION, ... (9 entities in total)
Functional Keywordsautotaxin, enpp2, inhibitor, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
Biological sourceHomo sapiens (Human)
Cellular locationSecreted : Q13822
Total number of polymer chains2
Total formula weight200014.88
Authors
Stein, A.J.,Bain, G.,Hutchinson, J.H.,Evans, J.F. (deposition date: 2015-04-22, release date: 2015-10-14, Last modification date: 2023-09-27)
Primary citationStein, A.J.,Bain, G.,Prodanovich, P.,Santini, A.M.,Darlington, J.,Stelzer, N.M.,Sidhu, R.S.,Schaub, J.,Goulet, L.,Lonergan, D.,Calderon, I.,Evans, J.F.,Hutchinson, J.H.
Structural Basis for Inhibition of Human Autotaxin by Four Potent Compounds with Distinct Modes of Binding.
Mol.Pharmacol., 88:982-992, 2015
Cited by
PubMed: 26371182
DOI: 10.1124/mol.115.100404
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.8 Å)
Structure validation

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