4ZFC

Crystal structure of AKR1C3 complexed with glicazide

4ZFC の概要

• エントリーDOI: 10.2210/pdb4zfc/pdb
• 分子名称: Aldo-keto reductase family 1 member C3, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, N-[(3aR,6aS)-hexahydrocyclopenta[c]pyrrol-2(1H)-ylcarbamoyl]-4-methylbenzenesulfonamide, ... (4 entities in total)
• 機能のキーワード: akr1c3 inhibitor, oxidoreductase-oxidoreductase inhibitor complex, oxidoreductase/oxidoreductase inhibitor
• 由来する生物種: Homo sapiens (Human)
• 細胞内の位置: Cytoplasm: P42330
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 75946.09

構造登録者

Zhao, Y.,Zhrng, X.,Hu, X. (登録日: 2015-04-21, 公開日: 2015-11-25, 最終更新日: 2024-03-20)

• 主引用文献: Zhao, Y.,Zheng, X.,Zhang, H.,Zhai, J.,Zhang, L.,Li, C.,Zeng, K.,Chen, Y.,Li, Q.,Hu, X.; In vitro inhibition of AKR1Cs by sulphonylureas and the structural basis; Chem.Biol.Interact., 240:310-315, 2015; PubMed: 26362498; DOI: 10.1016/j.cbi.2015.09.006

実験手法

X-RAY DIFFRACTION (2 Å)