4ZER
Crystal structure of the Onc112 antimicrobial peptide bound to the Thermus thermophilus 70S ribosome
This is a non-PDB format compatible entry.
Summary for 4ZER
Entry DOI | 10.2210/pdb4zer/pdb |
Descriptor | 23s ribosomal RNA, 50S ribosomal protein L14, 50S ribosomal protein L15, ... (63 entities in total) |
Functional Keywords | bacterial ribosome, proline-rich antimicrobial peptide, antibiotics, protein biosynthesis, ribosome |
Biological source | Escherichia coli K-12 More |
Total number of polymer chains | 110 |
Total formula weight | 4412861.84 |
Authors | Seefeldt, A.C.,Nguyen, F.,Antunes, S.,Perebaskine, N.,Graf, M.,Arenz, S.,Inampudi, K.K.,Douat, C.,Guichard, G.,Wilson, D.N.,Innis, C.A. (deposition date: 2015-04-20, release date: 2015-05-20, Last modification date: 2024-01-10) |
Primary citation | Seefeldt, A.C.,Nguyen, F.,Antunes, S.,Perebaskine, N.,Graf, M.,Arenz, S.,Inampudi, K.K.,Douat, C.,Guichard, G.,Wilson, D.N.,Innis, C.A. The proline-rich antimicrobial peptide Onc112 inhibits translation by blocking and destabilizing the initiation complex. Nat.Struct.Mol.Biol., 22:470-475, 2015 Cited by PubMed: 25984971DOI: 10.1038/nsmb.3034 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3.1 Å) |
Structure validation
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