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4Z91

ELIC cocrystallized with isofluorane in a desensitized state

Summary for 4Z91
Entry DOI10.2210/pdb4z91/pdb
Related3RQU 3RQW
DescriptorGamma-aminobutyric-acid receptor subunit beta-1, (2R)-2-chloro-2-(difluoromethoxy)-1,1,1-trifluoroethane, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, ... (5 entities in total)
Functional Keywordselic, isoflurane, anesthetics, desensitized state, transport protein
Biological sourceDickeya dadantii (strain 3937)
Total number of polymer chains10
Total formula weight374240.46
Authors
Chen, Q.,Kinde, M.N.,Arjunan, P.,Cohen, A.,Xu, Y.,Tang, P. (deposition date: 2015-04-09, release date: 2015-09-16, Last modification date: 2023-09-27)
Primary citationChen, Q.,Kinde, M.N.,Arjunan, P.,Wells, M.M.,Cohen, A.E.,Xu, Y.,Tang, P.
Direct Pore Binding as a Mechanism for Isoflurane Inhibition of the Pentameric Ligand-gated Ion Channel ELIC.
Sci Rep, 5:13833-13833, 2015
Cited by
PubMed: 26346220
DOI: 10.1038/srep13833
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (3.3915 Å)
Structure validation

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