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4Z84

PKAB3 in complex with pyrrolidine inhibitor 34a

Summary for 4Z84
Entry DOI10.2210/pdb4z84/pdb
Related1Q61 4Z83
DescriptorcAMP-dependent protein kinase catalytic subunit alpha, cAMP-dependent protein kinase inhibitor alpha, 7-[(3S,4R)-4-(3-chlorophenyl)carbonylpyrrolidin-3-yl]-3H-quinazolin-4-one, ... (5 entities in total)
Functional Keywordsinhibitor, protein kinase, structure-guided, transferase
Biological sourceBos taurus (Bovine)
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Cellular locationCytoplasm : P00517
Total number of polymer chains2
Total formula weight43472.94
Authors
Lund, B.A.,Alam, K.A.,Engh, R.A. (deposition date: 2015-04-08, release date: 2015-12-02, Last modification date: 2024-01-10)
Primary citationLauber, B.S.,Hardegger, L.A.,Asraful, A.K.,Lund, B.A.,Dumele, O.,Harder, M.,Kuhn, B.,Engh, R.A.,Diederich, F.
Addressing the Glycine-Rich Loop of Protein Kinases by a Multi-Facetted Interaction Network: Inhibition of PKA and a PKB Mimic.
Chemistry, 22:211-221, 2016
Cited by
PubMed: 26578105
DOI: 10.1002/chem.201503552
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.554 Å)
Structure validation

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