4Z7A

Structural and biochemical characterization of a non-functionally redundant M. tuberculosis (3,3) L,D-Transpeptidase, LdtMt5.

Summary for 4Z7A

Entry DOI	10.2210/pdb4z7a/pdb
Related	3TUR 3TX4 3U1P 3U1Q 3VAE
Descriptor	Mycobacterium tuberculosis (3,3)L,D-Transpeptidase type 5, PHOSPHATE ION, DI(HYDROXYETHYL)ETHER, ... (6 entities in total)
Functional Keywords	peptidoglycan, cell wall biosynthesis, carbapenems, nitrocefin, enzyme kinetics, enzyme structure, antibiotics, cell wall, transferase
Biological source	Mycobacterium tuberculosis (strain ATCC 25177 / H37Ra)
Total number of polymer chains	1
Total formula weight	48327.83
Authors	Basta, L.,Ghosh, A.,Pan, Y.,Jakoncic, J.,Lloyd, E.,Townsend, G.,Lamichhane, G.,Bianchet, M.A. (deposition date: 2015-04-06, release date: 2015-09-02, Last modification date: 2023-09-27)
Primary citation	Brammer Basta, L.A.,Ghosh, A.,Pan, Y.,Jakoncic, J.,Lloyd, E.P.,Townsend, C.A.,Lamichhane, G.,Bianchet, M.A. Loss of a Functionally and Structurally Distinct ld-Transpeptidase, LdtMt5, Compromises Cell Wall Integrity in Mycobacterium tuberculosis. J.Biol.Chem., 290:25670-25685, 2015 Cited by PubMed: 26304120 DOI: 10.1074/jbc.M115.660753 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.98 Å)

Structure validation