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4Z55

Anaplastic lymphoma kinase catalytic domain complexed with pyrazolopyrimidine derivative of LDK378

Summary for 4Z55
Entry DOI10.2210/pdb4z55/pdb
Related3L9P 3LCS 3LCT 4MKC
DescriptorALK tyrosine kinase receptor, GLYCEROL, N~6~-[5-methyl-4-(1-methylpiperidin-4-yl)-2-(propan-2-yloxy)phenyl]-N~4~-[2-(propan-2-ylsulfonyl)phenyl]-2H-pyrazolo[3,4-d]pyrimidine-4,6-diamine, ... (4 entities in total)
Functional Keywordscatalytic domain, transferase, inhibitor, transferase-transferase inhibitor complex, transferase/transferase inhibitor
Biological sourceHomo sapiens (Human)
Cellular locationCell membrane ; Single-pass type I membrane protein : Q9UM73
Total number of polymer chains1
Total formula weight38999.80
Authors
Lee, C.C.,Spraggon, G. (deposition date: 2015-04-02, release date: 2016-02-03, Last modification date: 2024-03-06)
Primary citationMichellys, P.Y.,Chen, B.,Jiang, T.,Jin, Y.,Lu, W.,Marsilje, T.H.,Pei, W.,Uno, T.,Zhu, X.,Wu, B.,Nguyen, T.N.,Bursulaya, B.,Lee, C.,Li, N.,Kim, S.,Tuntland, T.,Liu, B.,Sun, F.,Steffy, A.,Hood, T.
Design and synthesis of novel selective anaplastic lymphoma kinase inhibitors.
Bioorg.Med.Chem.Lett., 26:1090-1096, 2016
Cited by
PubMed: 26750252
DOI: 10.1016/j.bmcl.2015.11.049
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.55 Å)
Structure validation

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