4YVV

Crystal structure of AKR1C3 complexed with glibenclamide

Summary for 4YVV

• Entry DOI: 10.2210/pdb4yvv/pdb
• Related: 4YVP 4YVX
• Descriptor: Aldo-keto reductase family 1 member C3, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, 5-chloro-N-(2-{4-[(cyclohexylcarbamoyl)sulfamoyl]phenyl}ethyl)-2-methoxybenzamide, ... (4 entities in total)
• Functional Keywords: akr1c3 inhibitor, oxidoreductase-oxidoreductase inhibitor complex, oxidoreductase/oxidoreductase inhibitor
• Biological source: Homo sapiens (Human)
• Cellular location: Cytoplasm: P42330
• Total number of polymer chains: 2
• Total formula weight: 76287.28

Authors

Zhao, Y.,Zheng, X.,Zhang, H.,Hu, X. (deposition date: 2015-03-20, release date: 2015-11-25, Last modification date: 2023-11-08)

• Primary citation: Zhao, Y.,Zheng, X.,Zhang, H.,Zhai, J.,Zhang, L.,Li, C.,Zeng, K.,Chen, Y.,Li, Q.,Hu, X.; In vitro inhibition of AKR1Cs by sulphonylureas and the structural basis; Chem.Biol.Interact., 240:310-315, 2015; PubMed: 26362498; DOI: 10.1016/j.cbi.2015.09.006

Experimental method

X-RAY DIFFRACTION (2.3 Å)