4YT1

Human PPAR Gamma Ligand Binding Domain in complex with a Gammma Selective Synthetic Partial Agonist MEKT76

Summary for 4YT1

Entry DOI	10.2210/pdb4yt1/pdb
Descriptor	Peroxisome proliferator-activated receptor gamma, N-(benzylsulfonyl)-4-propoxy-3-({[4-(pyrimidin-2-yl)benzoyl]amino}methyl)benzamide (3 entities in total)
Functional Keywords	nuclear receptor, transcription
Biological source	Homo sapiens (Human)
Total number of polymer chains	2
Total formula weight	65605.93
Authors	Oyama, T.,Ohashi, M.,Miyachi, H.,Kusunoki, M. (deposition date: 2015-03-17, release date: 2016-03-02, Last modification date: 2023-11-08)
Primary citation	Ohashi, M.,Gamo, K.,Oyama, T.,Miyachi, H. Peroxisome proliferator-activated receptor gamma (PPAR gamma ) has multiple binding points that accommodate ligands in various conformations: Structurally similar PPAR gamma partial agonists bind to PPAR gamma LBD in different conformations Bioorg.Med.Chem.Lett., 25:2758-2762, 2015 Cited by PubMed: 26025876 DOI: 10.1016/j.bmcl.2015.05.025 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.2 Å)

Structure validation