4YPQ

Crystal structure of the ROR(gamma)t ligand binding domain in complex with 4-(1-(2-chloro-6-(trifluoromethyl)benzoyl)-1H-indazol-3-yl)benzoic acid

Summary for 4YPQ

Entry DOI	10.2210/pdb4ypq/pdb
Descriptor	Nuclear receptor ROR-gamma, 4-{1-[2-chloro-6-(trifluoromethyl)benzoyl]-1H-indazol-3-yl}benzoic acid, MAGNESIUM ION, ... (4 entities in total)
Functional Keywords	nuclear receptor ligand binding domain, transcription
Biological source	Homo sapiens (Human)
Cellular location	Nucleus : P51449
Total number of polymer chains	1
Total formula weight	28776.92
Authors	Leysen, S.,Scheepstra, M.,van Almen, G.C.,Ottmann, C.,Brunsveld, L. (deposition date: 2015-03-13, release date: 2015-12-23, Last modification date: 2024-01-10)
Primary citation	Scheepstra, M.,Leysen, S.,van Almen, G.C.,Miller, J.R.,Piesvaux, J.,Kutilek, V.,van Eenennaam, H.,Zhang, H.,Barr, K.,Nagpal, S.,Soisson, S.M.,Kornienko, M.,Wiley, K.,Elsen, N.,Sharma, S.,Correll, C.C.,Trotter, B.W.,van der Stelt, M.,Oubrie, A.,Ottmann, C.,Parthasarathy, G.,Brunsveld, L. Identification of an allosteric binding site for ROR gamma t inhibition. Nat Commun, 6:8833-8833, 2015 Cited by PubMed: 26640126 DOI: 10.1038/ncomms9833 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.32 Å)

Structure validation