4YNK

Crystal structure of vitamin D receptor ligand binding domain complexed with a 19-norvitamin D compound

Summary for 4YNK

• Entry DOI: 10.2210/pdb4ynk/pdb
• Descriptor: Vitamin D3 receptor,Vitamin D3 receptor, Coactivator peptide drip from cDNA FLJ50196, highly similar to Peroxisome proliferator-activated receptor-binding protein, (1R,3R,7E,17beta)-17-{(5S)-5-hydroxy-5-[(3R,5R,7R)-tricyclo[3.3.1.1~3,7~]dec-1-yl]penta-1,3-diyn-1-yl}-2-methylidene-9,10-secoestra-5,7-diene-1,3-diol, ... (4 entities in total)
• Functional Keywords: transcription, hormone receptor
• Biological source: Rattus norvegicus (Rat); More
• Total number of polymer chains: 2
• Total formula weight: 32666.65

Authors

Watarai, Y.,Ikura, T.,Ito, N. (deposition date: 2015-03-10, release date: 2016-01-20, Last modification date: 2023-11-08)

• Primary citation: Watarai, Y.,Ishizawa, M.,Ikura, T.,Zacconi, F.C.,Uno, S.,Ito, N.,Mourino, A.,Tokiwa, H.,Makishima, M.,Yamada, S.; Synthesis, Biological Activities, and X-ray Crystal Structural Analysis of 25-Hydroxy-25(or 26)-adamantyl-17-[20(22),23-diynyl]-21-norvitamin D Compounds; J.Med.Chem., 58:9510-9521, 2015; PubMed: 26613420; DOI: 10.1021/acs.jmedchem.5b00792

Experimental method

X-RAY DIFFRACTION (2.3 Å)