Loading
PDBj
MenuPDBj@FacebookPDBj@TwitterPDBj@YouTubewwPDB FoundationwwPDB
RCSB PDBPDBeBMRBAdv. SearchSearch help

4YND

The Discovery of A-893, A New Cell-Active Benzoxazinone Inhibitor of Lysine Methyltransferase SMYD2

Summary for 4YND
Entry DOI10.2210/pdb4ynd/pdb
DescriptorN-lysine methyltransferase SMYD2, ZINC ION, N-cyclohexyl-N~3~-[2-(3,4-dichlorophenyl)ethyl]-N-(2-{[(2R)-2-hydroxy-2-(3-oxo-3,4-dihydro-2H-1,4-benzoxazin-8-yl)ethyl]amino}ethyl)-beta-alaninamide, ... (5 entities in total)
Functional Keywordsepigenetics, smyd2, h3k36, p53, methyltransferase, lysine, transferase-inhibitor complex, transferase/inhibitor
Biological sourceHomo sapiens (Human)
Cellular locationCytoplasm, cytosol : Q9NRG4
Total number of polymer chains1
Total formula weight54378.00
Authors
Sweis, R.F.,Wang, Z.,Algire, M.,Arrowsmith, C.H.,Brown, P.J.,Chiang, G.C.,Guo, J.,Jakob, C.G.,Kennedy, S.,Li, F.,Soni, N.B.,Vedadi, M.,Pappano, W.N. (deposition date: 2015-03-09, release date: 2015-05-20, Last modification date: 2023-09-27)
Primary citationSweis, R.F.,Wang, Z.,Algire, M.,Arrowsmith, C.H.,Brown, P.J.,Chiang, G.G.,Guo, J.,Jakob, C.G.,Kennedy, S.,Li, F.,Maag, D.,Shaw, B.,Soni, N.B.,Vedadi, M.,Pappano, W.N.
Discovery of A-893, A New Cell-Active Benzoxazinone Inhibitor of Lysine Methyltransferase SMYD2.
Acs Med.Chem.Lett., 6:695-700, 2015
Cited by
PubMed: 26101576
DOI: 10.1021/acsmedchemlett.5b00124
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.79 Å)
Structure validation

217705

PDB entries from 2024-03-27

PDB statisticsPDBj update infoContact PDBjnumon