4YK5

Crystal Structures of mPGES-1 Inhibitor Complexes

Summary for 4YK5

Entry DOI	10.2210/pdb4yk5/pdb
Descriptor	Prostaglandin E synthase, 3-[1-(4-chlorobenzyl)-5-(2-fluoro-2'-methylbiphenyl-4-yl)-3-methyl-1H-indol-2-yl]-2,2-dimethylpropanoic acid, 2-(2-METHOXYETHOXY)ETHANOL, ... (8 entities in total)
Functional Keywords	inflammation, isomerase-isomerase inhibitor complex, isomerase/isomerase inhibitor
Biological source	Homo sapiens (Human)
Cellular location	Membrane ; Multi-pass membrane protein : O14684
Total number of polymer chains	1
Total formula weight	18967.86
Authors	Luz, J.G.,Antonysamy, S.,Kuklish, S.L.,Fisher, M.J. (deposition date: 2015-03-04, release date: 2015-07-15, Last modification date: 2024-02-28)
Primary citation	Luz, J.G.,Antonysamy, S.,Kuklish, S.L.,Condon, B.,Lee, M.R.,Allison, D.,Yu, X.P.,Chandrasekhar, S.,Backer, R.,Zhang, A.,Russell, M.,Chang, S.S.,Harvey, A.,Sloan, A.V.,Fisher, M.J. Crystal Structures of mPGES-1 Inhibitor Complexes Form a Basis for the Rational Design of Potent Analgesic and Anti-Inflammatory Therapeutics. J.Med.Chem., 58:4727-4737, 2015 Cited by PubMed: 25961169 DOI: 10.1021/acs.jmedchem.5b00330 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.42 Å)

Structure validation