4YK0
Crystal structure of the CBP bromodomain in complex with CPI098
Summary for 4YK0
Entry DOI | 10.2210/pdb4yk0/pdb |
Descriptor | CREB-binding protein, (4R)-4-methyl-1,3,4,5-tetrahydro-2H-1,5-benzodiazepin-2-one, 1,2-ETHANEDIOL, ... (4 entities in total) |
Functional Keywords | cbp, cpi098, transferase |
Biological source | Homo sapiens (Human) |
Cellular location | Cytoplasm: Q92793 |
Total number of polymer chains | 4 |
Total formula weight | 55413.52 |
Authors | Bellon, S.F.,Jayaram, H. (deposition date: 2015-03-03, release date: 2016-04-20, Last modification date: 2024-02-28) |
Primary citation | Ghosh, S.,Taylor, A.,Chin, M.,Huang, H.R.,Conery, A.R.,Mertz, J.A.,Salmeron, A.,Dakle, P.J.,Mele, D.,Cote, A.,Jayaram, H.,Setser, J.W.,Poy, F.,Hatzivassiliou, G.,DeAlmeida-Nagata, D.,Sandy, P.,Hatton, C.,Romero, F.A.,Chiang, E.,Reimer, T.,Crawford, T.,Pardo, E.,Watson, V.G.,Tsui, V.,Cochran, A.G.,Zawadzke, L.,Harmange, J.C.,Audia, J.E.,Bryant, B.M.,Cummings, R.T.,Magnuson, S.R.,Grogan, J.L.,Bellon, S.F.,Albrecht, B.K.,Sims, R.J.,Lora, J.M. Regulatory T Cell Modulation by CBP/EP300 Bromodomain Inhibition. J.Biol.Chem., 291:13014-13027, 2016 Cited by PubMed: 27056325DOI: 10.1074/jbc.M115.708560 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.65 Å) |
Structure validation
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