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4YK0

Crystal structure of the CBP bromodomain in complex with CPI098

Summary for 4YK0
Entry DOI10.2210/pdb4yk0/pdb
DescriptorCREB-binding protein, (4R)-4-methyl-1,3,4,5-tetrahydro-2H-1,5-benzodiazepin-2-one, 1,2-ETHANEDIOL, ... (4 entities in total)
Functional Keywordscbp, cpi098, transferase
Biological sourceHomo sapiens (Human)
Cellular locationCytoplasm: Q92793
Total number of polymer chains4
Total formula weight55413.52
Authors
Bellon, S.F.,Jayaram, H. (deposition date: 2015-03-03, release date: 2016-04-20, Last modification date: 2024-02-28)
Primary citationGhosh, S.,Taylor, A.,Chin, M.,Huang, H.R.,Conery, A.R.,Mertz, J.A.,Salmeron, A.,Dakle, P.J.,Mele, D.,Cote, A.,Jayaram, H.,Setser, J.W.,Poy, F.,Hatzivassiliou, G.,DeAlmeida-Nagata, D.,Sandy, P.,Hatton, C.,Romero, F.A.,Chiang, E.,Reimer, T.,Crawford, T.,Pardo, E.,Watson, V.G.,Tsui, V.,Cochran, A.G.,Zawadzke, L.,Harmange, J.C.,Audia, J.E.,Bryant, B.M.,Cummings, R.T.,Magnuson, S.R.,Grogan, J.L.,Bellon, S.F.,Albrecht, B.K.,Sims, R.J.,Lora, J.M.
Regulatory T Cell Modulation by CBP/EP300 Bromodomain Inhibition.
J.Biol.Chem., 291:13014-13027, 2016
Cited by
PubMed: 27056325
DOI: 10.1074/jbc.M115.708560
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.65 Å)
Structure validation

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