4YJ4

Crystal structure of Bcl-xL in complex with the BIM BH3 domain containing Ile155-to-Arg and Glu158-to-phosphoserine mutations

Summary for 4YJ4

• Entry DOI: 10.2210/pdb4yj4/pdb
• Descriptor: Bcl-2-like protein 1, Bcl-2-like protein 1, BIM BH3 domain, ACETATE ION, ... (5 entities in total)
• Functional Keywords: bcl-xl, bim, bh3, apoptosis
• Biological source: Mus musculus (Mouse); More
• Cellular location: Mitochondrion membrane ; Single-pass membrane protein . Isoform Bcl-X(L): Mitochondrion inner membrane. Isoform Bcl-X(delta-TM): Cytoplasm: Q64373
• Total number of polymer chains: 2
• Total formula weight: 25136.20

Authors

Ku, B.,Ha, N.-C.,Oh, B.-H. (deposition date: 2015-03-03, release date: 2015-07-29, Last modification date: 2017-09-27)

• Primary citation: Kim, J.S.,Ku, B.,Woo, T.G.,Oh, A.Y.,Jung, Y.S.,Soh, Y.M.,Yeom, J.H.,Lee, K.,Park, B.J.,Oh, B.H.,Ha, N.C.; Conversion of cell-survival activity of Akt into apoptotic death of cancer cells by two mutations on the BIM BH3 domain.; Cell Death Dis, 6:e1804-e1804, 2015; PubMed: 26136077; DOI: 10.1038/cddis.2015.118

Experimental method

X-RAY DIFFRACTION (2.1 Å)