4YCU

Crystal structure of cladosporin in complex with human lysyl-tRNA synthetase

Summary for 4YCU

• Entry DOI: 10.2210/pdb4ycu/pdb
• Related: 4YCV 4YCW
• Descriptor: Lysine--tRNA ligase, Aminoacyl tRNA synthase complex-interacting multifunctional protein 2, cladosporin, ... (6 entities in total)
• Functional Keywords: inhibitor, complex, lysrs, cladosporin, ligase- ligase inhibitor complex, ligase/ ligase inhibitor
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 3
• Total formula weight: 124639.37

Authors

Fang, P.,Wang, J.,Guo, M. (deposition date: 2015-02-20, release date: 2015-06-10, Last modification date: 2019-12-25)

• Primary citation: Fang, P.,Han, H.,Wang, J.,Chen, K.,Chen, X.,Guo, M.; Structural Basis for Specific Inhibition of tRNA Synthetase by an ATP Competitive Inhibitor.; Chem. Biol., 22:734-744, 2015; PubMed: 26074468; DOI: 10.1016/j.chembiol.2015.05.007

Experimental method

X-RAY DIFFRACTION (2.1 Å)