4YC8
C-Helix-Out Binding of Dasatinib Analog to c-Abl Kinase
Summary for 4YC8
Entry DOI | 10.2210/pdb4yc8/pdb |
Related | 4YBK |
Descriptor | Tyrosine-protein kinase ABL1, 2-({6-[4-(2-hydroxyethyl)piperazin-1-yl]-2-methylpyrimidin-4-yl}amino)-N-(4-phenoxyphenyl)-1,3-thiazole-5-carboxamide, 1,2-ETHANEDIOL, ... (5 entities in total) |
Functional Keywords | kinase, c-helix-out, transferase |
Biological source | Homo sapiens (Human) |
Cellular location | Cytoplasm, cytoskeleton. Isoform IB: Nucleus membrane; Lipid-anchor: P00519 |
Total number of polymer chains | 2 |
Total formula weight | 68023.84 |
Authors | Kwarcinski, F.E.,Brandvold, K.B.,Johnson, T.J.,Phadke, S.,Meagher, J.L.,Seeliger, M.A.,Stuckey, J.A.,Soellner, M.B. (deposition date: 2015-02-19, release date: 2016-03-02, Last modification date: 2023-09-27) |
Primary citation | Kwarcinski, F.E.,Brandvold, K.R.,Phadke, S.,Beleh, O.M.,Johnson, T.K.,Meagher, J.L.,Seeliger, M.A.,Stuckey, J.A.,Soellner, M.B. Conformation-Selective Analogues of Dasatinib Reveal Insight into Kinase Inhibitor Binding and Selectivity. Acs Chem.Biol., 11:1296-1304, 2016 Cited by PubMed: 26895387DOI: 10.1021/acschembio.5b01018 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.9 Å) |
Structure validation
Download full validation report