4Y7R

Crystal structure of WDR5 in complex with MYC MbIIIb peptide

Summary for 4Y7R

• Entry DOI: 10.2210/pdb4y7r/pdb
• Descriptor: WD repeat-containing protein 5, MYC MbIIIb peptide, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, ... (5 entities in total)
• Functional Keywords: myc wdr5 cancer, dna binding protein
• Biological source: Homo sapiens (Human); More
• Cellular location: Nucleus : P61964
• Total number of polymer chains: 2
• Total formula weight: 35464.16

Authors

Sun, Q.,Phan, J.,Olejniczak, E.T.,Thomas, L.R.,Fesik, S.W.,Tansey, W.P. (deposition date: 2015-02-16, release date: 2015-04-15, Last modification date: 2023-09-27)

• Primary citation: Thomas, L.R.,Wang, Q.,Grieb, B.C.,Phan, J.,Foshage, A.M.,Sun, Q.,Olejniczak, E.T.,Clark, T.,Dey, S.,Lorey, S.,Alicie, B.,Howard, G.C.,Cawthon, B.,Ess, K.C.,Eischen, C.M.,Zhao, Z.,Fesik, S.W.,Tansey, W.P.; Interaction with WDR5 Promotes Target Gene Recognition and Tumorigenesis by MYC.; Mol.Cell, 58:440-452, 2015; PubMed: 25818646; DOI: 10.1016/j.molcel.2015.02.028

Experimental method

X-RAY DIFFRACTION (1.898 Å)