4Y73

Crystal structure of IRAK4 kinase domain with inhibitor

Summary for 4Y73

Entry DOI	10.2210/pdb4y73/pdb
Descriptor	Interleukin-1 receptor-associated kinase 4, 5-{[(1R,2S)-2-aminocyclohexyl]amino}-N-[1-methyl-3-(trifluoromethyl)-1H-pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide (3 entities in total)
Functional Keywords	kinase, inhibitor, transferase
Biological source	Homo sapiens (Human)
Cellular location	Cytoplasm : Q9NWZ3
Total number of polymer chains	4
Total formula weight	137742.62
Authors	Lesburg, C.A. (deposition date: 2015-02-13, release date: 2015-05-20, Last modification date: 2015-07-15)
Primary citation	Lim, J.,Altman, M.D.,Baker, J.,Brubaker, J.D.,Chen, H.,Chen, Y.,Fischmann, T.,Gibeau, C.,Kleinschek, M.A.,Leccese, E.,Lesburg, C.,Maclean, J.K.,Moy, L.Y.,Mulrooney, E.F.,Presland, J.,Rakhilina, L.,Smith, G.F.,Steinhuebel, D.,Yang, R. Discovery of 5-Amino-N-(1H-pyrazol-4-yl)pyrazolo[1,5-a]pyrimidine-3-carboxamide Inhibitors of IRAK4. Acs Med.Chem.Lett., 6:683-688, 2015 Cited by PubMed: 26101574 DOI: 10.1021/acsmedchemlett.5b00107 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.14 Å)

Structure validation