4Y00

Crystal Structure of Human TDP-43 RRM1 Domain with D169G Mutation in Complex with an Unmodified Single-stranded DNA

Summary for 4Y00

• Entry DOI: 10.2210/pdb4y00/pdb
• Related: 4Y0F
• Descriptor: TAR DNA-binding protein 43, DNA (5'-D(P*TP*TP*GP*AP*GP*CP*GP*T)-3') (3 entities in total)
• Functional Keywords: rna recognition motif 1 complex, dna binding protein-dna complex, dna binding protein/dna
• Biological source: Homo sapiens (Human); More
• Cellular location: Nucleus : Q13148
• Total number of polymer chains: 8
• Total formula weight: 60390.94

Authors

Chiang, C.H.,Kuo, P.H.,Yang, W.Z.,Yuan, H.S. (deposition date: 2015-02-05, release date: 2016-02-10, Last modification date: 2023-11-08)

• Primary citation: Chiang, C.H.,Grauffel, C.,Wu, L.S.,Kuo, P.H.,Doudeva, L.G.,Lim, C.,Shen, C.K.,Yuan, H.S.; Structural analysis of disease-related TDP-43 D169G mutation: linking enhanced stability and caspase cleavage efficiency to protein accumulation; Sci Rep, 6:21581-21581, 2016; PubMed: 26883171; DOI: 10.1038/srep21581

Experimental method

X-RAY DIFFRACTION (3 Å)