4XYC

NANOMOLAR INHIBITORS OF MYCOBACTERIUM TUBERCULOSIS GLUTAMINE SYNTHETASE 1: SYNTHESIS, BIOLOGICAL EVALUATION AND X-RAY CRYSTALLOGRAPHIC STUDIES

Summary for 4XYC

Entry DOI	10.2210/pdb4xyc/pdb
Descriptor	Glutamine synthetase 1, 9-phenyl-4H-imidazo[1,2-a]indeno[1,2-e]pyrazin-4-one (2 entities in total)
Functional Keywords	ligase, atp binding, ligase-ligase inhibitor complex, ligase/ligase inhibitor
Biological source	Mycobacterium tuberculosis
Cellular location	Cytoplasm : P9WN38
Total number of polymer chains	24
Total formula weight	1294200.89
Authors	Couturier, C.,Silve, S.,Morales, R.,Ppessegue, B.,Llopart, S.,Nair, A.,Bauer, A.,Scheiper, B.,poeverlein, c.,Ganzhorn, A.,Lagrange, S.,Bacque, E. (deposition date: 2015-02-02, release date: 2015-03-25, Last modification date: 2024-01-10)
Primary citation	Couturier, C.,Silve, S.,Morales, R.,Pessegue, B.,Llopart, S.,Nair, A.,Bauer, A.,Scheiper, B.,Poverlein, C.,Ganzhorn, A.,Lagrange, S.,Bacque, E. Nanomolar inhibitors of Mycobacterium tuberculosis glutamine synthetase 1: Synthesis, biological evaluation and X-ray crystallographic studies. Bioorg.Med.Chem.Lett., 25:1455-1459, 2015 Cited by PubMed: 25770781 DOI: 10.1016/j.bmcl.2015.02.035 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (3.3 Å)

Structure validation