4XY9

Crystal Structure of the first bromodomain of human BRD4 in complex with a 2-amine-9H-purine ligand

Summary for 4XY9

Entry DOI	10.2210/pdb4xy9/pdb
Descriptor	Bromodomain-containing protein 4, 1,2-ETHANEDIOL, 6-(5-bromo-2-methoxyphenyl)-9H-purin-2-amine, ... (4 entities in total)
Functional Keywords	bromodomain, complex, ligand, structural genomics consortium, sgc, transcription
Biological source	Homo sapiens (Human)
Cellular location	Nucleus: O60885
Total number of polymer chains	1
Total formula weight	15481.59
Authors	Picaud, S.,von Delft, F.,Edwards, A.M.,Arrowsmith, C.H.,Bountra, C.,Filippakopoulos, P.,Structural Genomics Consortium (SGC) (deposition date: 2015-02-02, release date: 2015-03-11, Last modification date: 2015-04-08)
Primary citation	Picaud, S.,Strocchia, M.,Terracciano, S.,Lauro, G.,Mendez, J.,Daniels, D.L.,Riccio, R.,Bifulco, G.,Bruno, I.,Filippakopoulos, P. 9H-Purine Scaffold Reveals Induced-Fit Pocket Plasticity of the BRD9 Bromodomain. J.Med.Chem., 58:2718-2736, 2015 Cited by PubMed: 25703523 DOI: 10.1021/jm501893k PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.83 Å)

Structure validation