4XXD
Crystal Structure of mid-region amyloid beta capture by solanezumab
Summary for 4XXD
Entry DOI | 10.2210/pdb4xxd/pdb |
Descriptor | Fab Light Chain, Fab Heavy Chain, Amyloid-beta fragment, ... (4 entities in total) |
Functional Keywords | fab, amyloid-beta, immune system |
Biological source | Homo sapiens More |
Cellular location | Membrane; Single-pass type I membrane protein: P05067 |
Total number of polymer chains | 6 |
Total formula weight | 99473.10 |
Authors | Hermans, S.J.,Crespi, G.A.N.,Parker, M.W.,Miles, L.A. (deposition date: 2015-01-30, release date: 2015-04-29, Last modification date: 2023-09-27) |
Primary citation | Crespi, G.A.,Hermans, S.J.,Parker, M.W.,Miles, L.A. Molecular basis for mid-region amyloid-beta capture by leading Alzheimer's disease immunotherapies. Sci Rep, 5:9649-9649, 2015 Cited by PubMed: 25880481DOI: 10.1038/srep09649 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.41 Å) |
Structure validation
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