4XVE

17beta-HSD5 in complex with 3-pentyl-2-[(pyridin-2-ylmethyl)sulfanyl]-7-(pyrrolidin-1-ylcarbonyl)quinazolin-4(3H)-one

Summary for 4XVE

• Entry DOI: 10.2210/pdb4xve/pdb
• Related: 4WDT 4WDU 4WDW 4WDX 4XVD
• Descriptor: Aldo-keto reductase family 1 member C3, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, 3-pentyl-2-[(pyridin-2-ylmethyl)sulfanyl]-7-(pyrrolidin-1-ylcarbonyl)quinazolin-4(3H)-one, ... (4 entities in total)
• Functional Keywords: aldo-keto reductase inhibitor, oxidoreductase-oxidoreductase inhibitor complex, oxidoreductase/oxidoreductase inhibitor
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 1
• Total formula weight: 39157.35

Authors

Amano, Y.,Yamaguchi, T. (deposition date: 2015-01-27, release date: 2015-04-15, Last modification date: 2023-11-08)

• Primary citation: Amano, Y.,Yamaguchi, T.,Niimi, T.,Sakashita, H.; Structures of complexes of type 5 17 beta-hydroxysteroid dehydrogenase with structurally diverse inhibitors: insights into the conformational changes upon inhibitor binding.; Acta Crystallogr.,Sect.D, 71:918-927, 2015; PubMed: 25849402; DOI: 10.1107/S1399004715002175

Experimental method

X-RAY DIFFRACTION (1.55 Å)