4XT1

Structure of a nanobody-bound viral GPCR bound to human chemokine CX3CL1

Summary for 4XT1

Entry DOI	10.2210/pdb4xt1/pdb
Related	4XT3
Descriptor	G-protein coupled receptor homolog US28, Fractalkine, nanobody 7, ... (8 entities in total)
Functional Keywords	gpcr, chemokine, membrane protein, complex, viral protein-signalling protein complex, viral protein/signalling protein
Biological source	Cytomegalovirus More
Cellular location	Host cell membrane; Multi-pass membrane protein: P69332 Cell membrane; Single-pass type I membrane protein. Processed fractalkine: Secreted: P78423
Total number of polymer chains	3
Total formula weight	69666.35
Authors	Burg, J.S.,Jude, K.M.,Waghray, D.,Garcia, K.C. (deposition date: 2015-01-22, release date: 2015-03-04, Last modification date: 2023-09-27)
Primary citation	Burg, J.S.,Ingram, J.R.,Venkatakrishnan, A.J.,Jude, K.M.,Dukkipati, A.,Feinberg, E.N.,Angelini, A.,Waghray, D.,Dror, R.O.,Ploegh, H.L.,Garcia, K.C. Structural biology. Structural basis for chemokine recognition and activation of a viral G protein-coupled receptor. Science, 347:1113-1117, 2015 Cited by PubMed: 25745166 DOI: 10.1126/science.aaa5026 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.886 Å)

Structure validation