4XI3

Estrogen Receptor Alpha Ligand Binding Domain in Complex with Bazedoxifene

Summary for 4XI3

Entry DOI	10.2210/pdb4xi3/pdb
Descriptor	Estrogen receptor, Bazedoxifene (3 entities in total)
Functional Keywords	estrogen receptor, serm, bazedoxifene, breast cancer, nuclear hormone receptor, signaling protein
Biological source	Homo sapiens (Human)
Total number of polymer chains	4
Total formula weight	112960.98
Authors	Fanning, S.W.,Mayne, C.G.,Toy, W.,Carlson, K.,Greene, B.,Nowak, J.,Walter, R.,Panchamukhi, S.,Tajhorshid, E.,Nettles, K.W.,Chandarlapaty, S.,Katzenellenbogen, J.,Greene, G.L. (deposition date: 2015-01-06, release date: 2016-01-13, Last modification date: 2024-03-06)
Primary citation	Fanning, S.W.,Jeselsohn, R.,Dharmarajan, V.,Mayne, C.G.,Karimi, M.,Buchwalter, G.,Houtman, R.,Toy, W.,Fowler, C.E.,Han, R.,Laine, M.,Carlson, K.E.,Martin, T.A.,Nowak, J.,Nwachukwu, J.C.,Hosfield, D.J.,Chandarlapaty, S.,Tajkhorshid, E.,Nettles, K.W.,Griffin, P.R.,Shen, Y.,Katzenellenbogen, J.A.,Brown, M.,Greene, G.L. The SERM/SERD bazedoxifene disrupts ESR1 helix 12 to overcome acquired hormone resistance in breast cancer cells. Elife, 7:-, 2018 Cited by PubMed: 30489256 DOI: 10.7554/eLife.37161 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.491 Å)

Structure validation