4XC1

Crystal structure of human 4E10 Fab in complex with its peptide epitope on HIV-1 GP41: crystals cryoprotected with sn-Glycerol 3-phosphate

Summary for 4XC1

Entry DOI	10.2210/pdb4xc1/pdb
Related	4XAW 4XBE 4XBG 4XBP 4XC3 4XCC 4XCE 4XCF 4XCN 4XCY
Descriptor	4E10 FAB LIGHT CHAIN, 4E10 FAB HEAVY CHAIN, MODIFIED FRAGMENT OF HIV-1 GLYCOPROTEIN (GP41) INCLUDING THE MPER REGION 671-683, ... (6 entities in total)
Functional Keywords	hiv-1 gp41 mper, 4e10 fab, lipid membrane, immune system
Biological source	Homo sapiens More
Total number of polymer chains	3
Total formula weight	50422.40
Authors	Irimia, A.,Stanfield, R.L.,Wilson, I.A. (deposition date: 2014-12-17, release date: 2016-02-03, Last modification date: 2023-11-15)
Primary citation	Irimia, A.,Sarkar, A.,Stanfield, R.L.,Wilson, I.A. Crystallographic Identification of Lipid as an Integral Component of the Epitope of HIV Broadly Neutralizing Antibody 4E10. Immunity, 44:21-31, 2016 Cited by PubMed: 26777395 DOI: 10.1016/j.immuni.2015.12.001 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.63 Å)

Structure validation