4XA5

Crystal structure of the pre-catalytic ternary complex of DNA polymerase lambda with a templating A and an incoming 8-oxo-dGTP

Summary for 4XA5

• Entry DOI: 10.2210/pdb4xa5/pdb
• Related: 4X5V
• Descriptor: DNA polymerase lambda, DOWNSTREAM PRIMER DNA (5'-D(P*GP*CP*CP*G)-3'), PRIMER DNA (5'-D(*CP*AP*GP*TP*AP*(DOC))-3'), ... (9 entities in total)
• Functional Keywords: dna polymerase lambda, protein-dna complex, helix-hairpin-helix, transferase-dna complex, transferase/dna
• Biological source: Homo sapiens (Human); More
• Cellular location: Nucleus: Q9UGP5
• Total number of polymer chains: 4
• Total formula weight: 43828.93

Authors

Burak, M.J.,Guja, K.E.,Garcia-Diaz, M. (deposition date: 2014-12-12, release date: 2016-02-10)

• Primary citation: Burak, M.J.,Guja, K.E.,Garcia-Diaz, M.; Nucleotide binding interactions modulate dNTP selectivity and facilitate 8-oxo-dGTP incorporation by DNA polymerase lambda.; Nucleic Acids Res., 43:8089-8099, 2015; PubMed: 26220180; DOI: 10.1093/nar/gkv760

Experimental method

X-RAY DIFFRACTION (1.9 Å)