4X63

Crystal structure of PRMT5:MEP50 with EPZ015666 and SAH

Summary for 4X63

• Entry DOI: 10.2210/pdb4x63/pdb
• Related: 4X60 4X61
• Descriptor: Protein arginine N-methyltransferase 5, Methylosome protein 50, S-ADENOSYL-L-HOMOCYSTEINE, ... (5 entities in total)
• Functional Keywords: protein-inhibitor complex, protein arginine methyltransferase, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• Biological source: Homo sapiens (Human); More
• Cellular location: Cytoplasm: O14744; Nucleus: Q9BQA1
• Total number of polymer chains: 2
• Total formula weight: 112393.89

Authors

Boriack-Sjodin, P.A. (deposition date: 2014-12-06, release date: 2015-04-22, Last modification date: 2015-05-27)

• Primary citation: Chan-Penebre, E.,Kuplast, K.G.,Majer, C.R.,Boriack-Sjodin, P.A.,Wigle, T.J.,Johnston, L.D.,Rioux, N.,Munchhof, M.J.,Jin, L.,Jacques, S.L.,West, K.A.,Lingaraj, T.,Stickland, K.,Ribich, S.A.,Raimondi, A.,Scott, M.P.,Waters, N.J.,Pollock, R.M.,Smith, J.J.,Barbash, O.,Pappalardi, M.,Ho, T.F.,Nurse, K.,Oza, K.P.,Gallagher, K.T.,Kruger, R.,Moyer, M.P.,Copeland, R.A.,Chesworth, R.,Duncan, K.W.; A selective inhibitor of PRMT5 with in vivo and in vitro potency in MCL models.; Nat.Chem.Biol., 11:432-437, 2015; PubMed: 25915199; DOI: 10.1038/nchembio.1810

Experimental method

X-RAY DIFFRACTION (3.05 Å)