4X5A
Anthranilate phosphoribosyltransferase variant R193A from Mycobacterium tuberculosis remains ligand-free when co-crystallised with PRPP and Mg
Summary for 4X5A
| Entry DOI | 10.2210/pdb4x5a/pdb |
| Related | 4X58 4X59 4X5B 4X5C 4X5D 4X5E |
| Descriptor | Anthranilate phosphoribosyltransferase, GLYCEROL (3 entities in total) |
| Functional Keywords | anthranilate phosphoribosyltransferase, anthranilic acids, mycobacterium tuberculosis, magnesium, tryptophan, mutation, transferase, magnesium binding, phosphoribosyl pyrophosphate |
| Biological source | Mycobacterium tuberculosis |
| Total number of polymer chains | 2 |
| Total formula weight | 77986.00 |
| Authors | Cookson, T.V.M.,Parker, E.J.,Lott, J.S. (deposition date: 2014-12-05, release date: 2015-11-25, Last modification date: 2023-09-27) |
| Primary citation | Cookson, T.V.,Evans, G.L.,Castell, A.,Baker, E.N.,Lott, J.S.,Parker, E.J. Structures of Mycobacterium tuberculosis Anthranilate Phosphoribosyltransferase Variants Reveal the Conformational Changes That Facilitate Delivery of the Substrate to the Active Site. Biochemistry, 54:6082-6092, 2015 Cited by PubMed: 26356348DOI: 10.1021/acs.biochem.5b00612 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (1.93 Å) |
Structure validation
Download full validation report
