4X59

Anthranilate phosphoribosyltransferase variant P180A from Mycobacterium tuberculosis in complex with PRPP and Mg

4X59 の概要

• エントリーDOI: 10.2210/pdb4x59/pdb
• 関連するPDBエントリー: 4X58 4X5A 4X5B 4X5C 4X5D 4X5E
• 分子名称: Anthranilate phosphoribosyltransferase, 1-O-pyrophosphono-5-O-phosphono-alpha-D-ribofuranose, GLYCEROL, ... (6 entities in total)
• 機能のキーワード: anthranilate phosphoribosyltransferase, anthranilic acids, mycobacterium tuberculosis, magnesium, tryptophan, mutation, transferase, magnesium binding, phosphoribosyl pyrophosphate
• 由来する生物種: Mycobacterium tuberculosis
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 79165.17

構造登録者

Cookson, T.V.M.,Evans, G.L.,Parker, E.J.,Lott, J.S. (登録日: 2014-12-04, 公開日: 2015-11-25, 最終更新日: 2023-09-27)

• 主引用文献: Cookson, T.V.,Evans, G.L.,Castell, A.,Baker, E.N.,Lott, J.S.,Parker, E.J.; Structures of Mycobacterium tuberculosis Anthranilate Phosphoribosyltransferase Variants Reveal the Conformational Changes That Facilitate Delivery of the Substrate to the Active Site.; Biochemistry, 54:6082-6092, 2015; PubMed: 26356348; DOI: 10.1021/acs.biochem.5b00612

実験手法

X-RAY DIFFRACTION (1.8 Å)