4WQ2

Human calpain PEF(S) with (Z)-3-(6-bromondol-3-yl)-2-mercaptoacrylic acid bound

Summary for 4WQ2

Entry DOI	10.2210/pdb4wq2/pdb
Descriptor	Calpain small subunit 1, (2Z)-3-(6-bromo-1H-indol-3-yl)-2-sulfanylprop-2-enoic acid, CALCIUM ION, ... (5 entities in total)
Functional Keywords	calpain, domain vi, pef(s), human, calcium binding, protease, ef-hand, hydrolase
Biological source	Homo sapiens (Human)
Cellular location	Cytoplasm : P04632
Total number of polymer chains	2
Total formula weight	41198.42
Authors	Adams, S.E.,Rizkallah, P.J.,Miller, D.J.,Hallett, M.B.,Allemann, R.K. (deposition date: 2014-10-21, release date: 2015-09-02, Last modification date: 2024-01-10)
Primary citation	Adams, S.E.,Robinson, E.J.,Miller, D.J.,Rizkallah, P.J.,Hallett, M.B.,Allemann, R.K. Conformationally restricted calpain inhibitors. Chem Sci, 6:6865-6871, 2015 Cited by PubMed: 28757975 DOI: 10.1039/c5sc01158b PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.64 Å)

Structure validation