4WNI

Crystal structure of the T229K mutant of human GAPDH at 2.3 angstroems resolution

Summary for 4WNI

• Entry DOI: 10.2210/pdb4wni/pdb
• Related: 4WNC
• Descriptor: Glyceraldehyde-3-phosphate dehydrogenase, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, ZINC ION, ... (4 entities in total)
• Functional Keywords: glycolytic, rossman fold, nad cofactor, mutant, oxidoreductase
• Biological source: Homo sapiens (Human)
• Cellular location: Cytoplasm, cytosol : P04406
• Total number of polymer chains: 4
• Total formula weight: 146695.47

Authors

Garcin, E.D.,White, M.R. (deposition date: 2014-10-12, release date: 2014-12-03, Last modification date: 2023-09-27)

• Primary citation: White, M.R.,Khan, M.M.,Deredge, D.,Ross, C.R.,Quintyn, R.,Zucconi, B.E.,Wysocki, V.H.,Wintrode, P.L.,Wilson, G.M.,Garcin, E.D.; A Dimer Interface Mutation in Glyceraldehyde-3-Phosphate Dehydrogenase Regulates Its Binding to AU-rich RNA.; J.Biol.Chem., 290:1770-1785, 2015; PubMed: 25451934; DOI: 10.1074/jbc.M114.618165

Experimental method

X-RAY DIFFRACTION (2.3 Å)