4WN5

Crystal structure of the C-terminal Per-Arnt-Sim (PASb) of human HIF-3alpha9 bound to 18:1-1-monoacylglycerol

Summary for 4WN5

• Entry DOI: 10.2210/pdb4wn5/pdb
• Descriptor: Hypoxia-inducible factor 3-alpha, SULFATE ION, MONOVACCENIN, ... (5 entities in total)
• Functional Keywords: hif-3alpha, pas domain, monoacylglycerol, lipid, fatty acid, transcription
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 2
• Total formula weight: 27358.77

Authors

Fala, A.M.,Oliveira, J.F.,Dias, S.M.,Ambrosio, A.L. (deposition date: 2014-10-10, release date: 2015-08-05, Last modification date: 2023-09-27)

• Primary citation: Fala, A.M.,Oliveira, J.F.,Adamoski, D.,Aricetti, J.A.,Dias, M.M.,Dias, M.V.B.,Sforca, M.L.,Lopes-de-Oliveira, P.S.,Rocco, S.A.,Caldana, C.,Dias, S.M.G.,Ambrosio, A.L.B.; Unsaturated fatty acids as high-affinity ligands of the C-terminal Per-ARNT-Sim domain from the Hypoxia-inducible factor 3 alpha.; Sci Rep, 5:12698-12698, 2015; PubMed: 26237540; DOI: 10.1038/srep12698

Experimental method

X-RAY DIFFRACTION (1.15 Å)