4WJ7

CCM2 PTB domain in complex with KRIT1 NPxY/F3

Summary for 4WJ7

• Entry DOI: 10.2210/pdb4wj7/pdb
• Descriptor: Malcavernin, KRIT1 NPxY/F3 (3 entities in total)
• Functional Keywords: complex, ptb domain, npxy motif, protein binding
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 8
• Total formula weight: 83778.80

Authors

Fisher, O.S.,Liu, W.,Zhang, R.,Stiegler, A.L.,Boggon, T.J. (deposition date: 2014-09-29, release date: 2014-12-24, Last modification date: 2023-09-27)

• Primary citation: Fisher, O.S.,Liu, W.,Zhang, R.,Stiegler, A.L.,Ghedia, S.,Weber, J.L.,Boggon, T.J.; Structural Basis for the Disruption of the Cerebral Cavernous Malformations 2 (CCM2) Interaction with Krev Interaction Trapped 1 (KRIT1) by Disease-associated Mutations.; J.Biol.Chem., 290:2842-2853, 2015; PubMed: 25525273; DOI: 10.1074/jbc.M114.616433

Experimental method

X-RAY DIFFRACTION (2.753 Å)