4WHW

Direct photocapture of bromodomains using tropolone chemical probes

Summary for 4WHW

• Entry DOI: 10.2210/pdb4whw/pdb
• Descriptor: Bromodomain-containing protein 4, 2-methoxy-4-{1-[2-(morpholin-4-yl)ethyl]-2-(2-phenylethyl)-1H-benzimidazol-5-yl}cyclohepta-2,4,6-trien-1-one, 1,2-ETHANEDIOL, ... (4 entities in total)
• Functional Keywords: bromo domain, brd4, inhibitor, transcription-transcription inhibitor complex, transcription/transcription inhibitor
• Biological source: Homo sapiens (Human)
• Cellular location: Nucleus: O60885
• Total number of polymer chains: 1
• Total formula weight: 15631.02

Authors

Hett, E.C.,Piatnitski Chekler, E.L.,Basak, A.,Bonin, P.D.,Denny, R.A.,Flick, A.C.,Geoghegan, K.F.,Liu, S.,Pletcher, M.T.,Robinson, R.P.,Sahasrabudhe, P.,Salter, S.,Stock, I.A.,Jones, L.H. (deposition date: 2014-09-23, release date: 2015-10-28, Last modification date: 2023-12-27)

• Primary citation: Hett, E.C.,Piatnitski Chekler, E.L.,Basak, A.,Bonin, P.D.,Denny, R.A.,Flick, A.C.,Geoghegan, K.F.,Liu, S.,Pletcher, M.T.,Robinson, R.P.,Sahasrabudhe, P.,Salter, S.,Stock, I.A.,Jones, L.H.; Direct photocapture of bromodomains using tropolone chemical probes; To Be Published,

Experimental method

X-RAY DIFFRACTION (1.345 Å)