4WHV

E3 ubiquitin-protein ligase RNF8 in complex with Ubiquitin-conjugating enzyme E2 N and Polyubiquitin-B

Summary for 4WHV

• Entry DOI: 10.2210/pdb4whv/pdb
• Related: 4ORH
• Descriptor: Ubiquitin-conjugating enzyme E2 N, E3 ubiquitin-protein ligase RNF8, Polyubiquitin-B, ... (4 entities in total)
• Functional Keywords: e3 ligase, e2 conjugating enzyme, ubiquitination, coiled coil, ligase-protein binding complex, ligase/protein binding
• Biological source: Homo sapiens (Human); More
• Cellular location: Nucleus : P61088 O76064; Ubiquitin: Cytoplasm : P0CG47
• Total number of polymer chains: 12
• Total formula weight: 180150.10

Authors

Hodge, C.D.,Edwards, R.A.,Glover, J.N.M. (deposition date: 2014-09-23, release date: 2015-09-30, Last modification date: 2023-09-27)

• Primary citation: Hodge, C.D.,Ismail, I.H.,Edwards, R.A.,Hura, G.L.,Xiao, A.T.,Tainer, J.A.,Hendzel, M.J.,Glover, J.N.; RNF8 E3 Ubiquitin Ligase Stimulates Ubc13 E2 Conjugating Activity That Is Essential for DNA Double Strand Break Signaling and BRCA1 Tumor Suppressor Recruitment.; J.Biol.Chem., 291:9396-9410, 2016; PubMed: 26903517; DOI: 10.1074/jbc.M116.715698

Experimental method

X-RAY DIFFRACTION (8.3 Å)