4WHL

A New Class of Peptidomimetics Targeting the Polo-box Domain of Polo-like kinase 1

Summary for 4WHL

Entry DOI	10.2210/pdb4whl/pdb
Related	4WHH 4WHK
Related PRD ID	PRD_002126
Descriptor	Serine/threonine-protein kinase PLK1, C6H5(CH2)8-DERIVATIZED PEPTIDE INHIBITOR (3 entities in total)
Functional Keywords	polo-like kinase, polo-box domain, inhibitor, peptide derivative, transferase-transferase inhibitor complex, transferase/transferase inhibitor
Biological source	Homo sapiens (Human) More
Cellular location	Nucleus: P53350
Total number of polymer chains	2
Total formula weight	28084.00
Authors	Bang, J.K.,Han, Y.H.,Ahn, M.J.,Lee, K.S. (deposition date: 2014-09-23, release date: 2014-12-03, Last modification date: 2023-11-15)
Primary citation	Ahn, M.,Han, Y.H.,Park, J.E.,Kim, S.,Lee, W.C.,Lee, S.J.,Gunasekaran, P.,Cheong, C.,Shin, S.Y.,Kim, H.Y.,Ryu, E.K.,Murugan, R.N.,Kim, N.H.,Bang, J.K. A new class of peptidomimetics targeting the polo-box domain of polo-like kinase 1. J.Med.Chem., 58:294-304, 2015 Cited by PubMed: 25347203 DOI: 10.1021/jm501147g PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.71 Å)

Structure validation