4WCU

PDE4 complexed with inhibitor

Summary for 4WCU

• Entry DOI: 10.2210/pdb4wcu/pdb
• Related: 4W1O
• Descriptor: cAMP-specific 3',5'-cyclic phosphodiesterase 4D, N-benzyl-2-{6-[(3,5-dichloropyridin-4-yl)acetyl]-2,3-dimethoxyphenoxy}acetamide, ZINC ION, ... (5 entities in total)
• Functional Keywords: inhibitor, complex, pde4d, hydrolase
• Biological source: Homo sapiens (Human)
• Cellular location: Apical cell membrane: Q08499
• Total number of polymer chains: 4
• Total formula weight: 167442.72

Authors

Sorensen, M.D. (deposition date: 2014-09-05, release date: 2014-10-08)

• Primary citation: Felding, J.,Sorensen, M.D.,Poulsen, T.D.,Larsen, J.,Andersson, C.,Refer, P.,Engell, K.,Ladefoged, L.G.,Thormann, T.,Vinggaard, A.M.,Hegardt, P.,Sohoel, A.,Nielsen, S.F.; Discovery and Early Clinical Development of 2-{6-[2-(3,5-Dichloro-4-pyridyl)acetyl]-2,3-dimethoxyphenoxy}-N-propylacetamide (LEO 29102), a Soft-Drug Inhibitor of Phosphodiesterase 4 for Topical Treatment of Atopic Dermatitis.; J. Med. Chem., 57:5893-5903, 2014; PubMed: 24984230; DOI: 10.1021/jm500378a

Experimental method

X-RAY DIFFRACTION (2.35 Å)