4WCI

Crystal structure of the 1st SH3 domain from human CD2AP (CMS) in complex with a proline-rich peptide (aa 378-393) from human RIN3

Summary for 4WCI

• Entry DOI: 10.2210/pdb4wci/pdb
• Related: 3U23
• Descriptor: CD2-associated protein, Ras and Rab interactor 3, SULFATE ION, ... (4 entities in total)
• Functional Keywords: endocytosis adaptor protein protein-peptide binary complex kidney, signaling protein, structural genomics, structural genomics consortium, sgc
• Biological source: Homo sapiens (Human); More
• Cellular location: Cytoplasm, cytoskeleton : Q9Y5K6; Cytoplasm : Q8TB24
• Total number of polymer chains: 6
• Total formula weight: 28448.12

Authors

Rouka, E.,Simister, P.C.,Janning, M.,Kirsch, K.H.,Krojer, T.,Knapp, S.,von Delft, F.,Arrowsmith, C.H.,Edwards, A.M.,Bountra, C.,Feller, S.M.,Structural Genomics Consortium (SGC) (deposition date: 2014-09-04, release date: 2015-08-19, Last modification date: 2024-01-10)

• Primary citation: Rouka, E.,Simister, P.C.,Janning, M.,Kumbrink, J.,Konstantinou, T.,Muniz, J.R.,Joshi, D.,O'Reilly, N.,Volkmer, R.,Ritter, B.,Knapp, S.,von Delft, F.,Kirsch, K.H.,Feller, S.M.; Differential Recognition Preferences of the Three Src Homology 3 (SH3) Domains from the Adaptor CD2-associated Protein (CD2AP) and Direct Association with Ras and Rab Interactor 3 (RIN3).; J.Biol.Chem., 290:25275-25292, 2015; PubMed: 26296892; DOI: 10.1074/jbc.M115.637207

Experimental method

X-RAY DIFFRACTION (1.65 Å)