4WCG

The binding mode of Cyprinid Herpesvirus3 ORF112-Zalpha to Z-DNA

Summary for 4WCG

• Entry DOI: 10.2210/pdb4wcg/pdb
• Related: 4HOB
• Descriptor: ORF112, DNA (5'-D(P*CP*GP*CP*GP*CP*G)-3'), SULFATE ION, ... (4 entities in total)
• Functional Keywords: zalpha, z-dna, innate immunity, herpes virus, dna binding protein
• Biological source: Cyprinid herpesvirus 3; More
• Total number of polymer chains: 4
• Total formula weight: 33584.26

Authors

Kus, K.,Athanasiadis, A. (deposition date: 2014-09-04, release date: 2015-11-18, Last modification date: 2024-01-10)

• Primary citation: Kus, K.,Rakus, K.,Boutier, M.,Tsigkri, T.,Gabriel, L.,Vanderplasschen, A.,Athanasiadis, A.; The Structure of the Cyprinid herpesvirus 3 ORF112-Z alpha Z-DNA Complex Reveals a Mechanism of Nucleic Acids Recognition Conserved with E3L, a Poxvirus Inhibitor of Interferon Response.; J.Biol.Chem., 290:30713-30725, 2015; PubMed: 26559969; DOI: 10.1074/jbc.M115.679407

Experimental method

X-RAY DIFFRACTION (1.5 Å)