4W9N

Enoyl-acyl carrier protein-reductase domain from human fatty acid synthase complexed with triclosan

Summary for 4W9N

• Entry DOI: 10.2210/pdb4w9n/pdb
• Related: 4W82
• Descriptor: Enoyl-[acyl-carrier-protein] reductase, IMIDAZOLE, CHLORIDE ION, ... (7 entities in total)
• Functional Keywords: fatty acid synthase, fatty acid metabolism, nadph-dependent, enoyl reductase, oxidoreductase
• Biological source: Homo sapiens (Human); More
• Cellular location: Cytoplasm : P49327 P49327
• Total number of polymer chains: 4
• Total formula weight: 148294.73

Authors

Sippel, K.H.,Vyas, N.K.,Sankaran, B.,Quiocho, F.A. (deposition date: 2014-08-27, release date: 2014-10-15, Last modification date: 2023-09-27)

• Primary citation: Sippel, K.H.,Vyas, N.K.,Zhang, W.,Sankaran, B.,Quiocho, F.A.; Crystal structure of the human Fatty Acid synthase enoyl-acyl carrier protein-reductase domain complexed with triclosan reveals allosteric protein-protein interface inhibition.; J.Biol.Chem., 289:33287-33295, 2014; PubMed: 25301948; DOI: 10.1074/jbc.M114.608547

Experimental method

X-RAY DIFFRACTION (1.84 Å)