4V0G

JAK3 in complex with a covalent EGFR inhibitor

Summary for 4V0G

• Entry DOI: 10.2210/pdb4v0g/pdb
• Descriptor: TYROSINE-PROTEIN KINASE JAK3, N-[3-(2-{3-amino-6-[1-(1-methylpiperidin-4-yl)-1H-pyrazol-4-yl]pyrazin-2-yl}-1H-benzimidazol-1-yl)phenyl]propanamide, ... (4 entities in total)
• Functional Keywords: transferase, egfr mutant, t790m
• Biological source: HOMO SAPIENS (HUMAN); More
• Cellular location: Endomembrane system ; Peripheral membrane protein : P52333 P52333
• Total number of polymer chains: 2
• Total formula weight: 65714.96

Authors

Debreczeni, J.E.,Hennessy, E.J.,Chuaquini, C.,Ashton, S.,Coclough, N.,Cross, D.A.E.,Eberlein, C.,Gingipalli, L.,Klinowska, T.C.M.,Orme, J.P.,Sha, L.,Wu, X. (deposition date: 2014-09-16, release date: 2016-01-13)

• Primary citation: Hennessy, E.J.,Chuaquini, C.,Ashton, S.,Coclough, N.,Cross, D.A.E.,Debreczeni, J.E.,Eberlein, C.,Gingipalli, L.,Klinowska, T.C.M.,Orme, J.P.,Sha, L.,Wu, X.; Utilisation of Structure Based Design to Identify Novel, Irreversible Inhibitors of the Epidermal Growth Factor Receptor (Egfr) Harboring the Gatekeeper T790M Mutation; To be Published,

Experimental method

X-RAY DIFFRACTION (3 Å)