4UYE

BROMODOMAIN OF HUMAN BRPF1 WITH N-1,3-dimethyl-2-oxo-6-(piperidin-1- yl)-2,3-dihydro-1H-1,3-benzodiazol-5-yl-2-methoxybenzamide

Summary for 4UYE

Entry DOI	10.2210/pdb4uye/pdb
Related	4UYD 4UYF 4UYG 4UYH
Descriptor	PEREGRIN, 1,2-ETHANEDIOL, N-[1,3-dimethyl-2-oxo-6-(piperidin-1-yl)-2,3-dihydro-1H-benzimidazol-5-yl]-2-methoxybenzamide, ... (4 entities in total)
Functional Keywords	transcription, inhibitor, histone, epigenetic reader, antagonist
Biological source	HOMO SAPIENS (HUMAN)
Cellular location	Nucleus : P55201
Total number of polymer chains	2
Total formula weight	28702.84
Authors	Chung, C.,Bamborough, P.,Demont, E. (deposition date: 2014-08-30, release date: 2014-09-17, Last modification date: 2014-12-03)
Primary citation	Demont, E.H.,Bamborough, P.,Chung, C.W.,Craggs, P.D.,Fallon, D.,Gordon, L.J.,Grandi, P.,Hobbs, C.I.,Hussain, J.,Jones, E.J.,Le Gall, A.,Michon, A.M.,Mitchell, D.J.,Prinjha, R.K.,Roberts, A.D.,Sheppard, R.J.,Watson, R.J. 1,3-Dimethyl Benzimidazolones are Potent, Selective Inhibitors of the Brpf1 Bromodomain. Acs Med.Chem.Lett., 5:1190-, 2014 Cited by PubMed: 25408830 DOI: 10.1021/ML5002932 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.65 Å)

Structure validation